Posts Tagged ‘progesterone’

Pregnancy after a premature birth

Friday, November 9th, 2018

If you had a premature birth in the past, you may be worried about having a premature birth in another pregnancy.

No one knows for sure what causes premature birth. Even if you do everything right, you can still give birth early. Women who have had a premature birth in the past are at increased risk of having a premature birth in another pregnancy. If you’ve given birth early, here are some things you can do to help reduce your risk for premature birth in your next pregnancy:

Wait 18 months between giving birth and getting pregnant again.

Waiting at least 18 months between pregnancies gives your body time to recover from one pregnancy so it’s ready for the next one. Use birth control so you don’t get pregnant again too soon. Talk to your health care provider about the best birth control option for you.

Get a preconception checkup.

This is a medical checkup you get before pregnancy to make sure you’re healthy when you get pregnant. Being as healthy as possible when you get pregnant can help you have a healthy, full-term pregnancy. At your preconception checkup you and your provider can talk about:

Talk to your provider about progesterone shots.

Progesterone is a hormone that helps your uterus grow and keeps it from having contractions. Progesterone shots may help prevent premature birth if both of these describe you:

  • You were pregnant before with just one baby and had spontaneous premature birth. Spontaneous premature birth means labor started on its own.
  • You’re pregnant with just one baby.

Talk to your provider about your risk for preeclampsia.

If you’re at risk for preeclampsia, your provider may recommend that you take low-dose aspirin (baby aspirin) to help prevent it. Preeclampsia is a kind of high blood pressure some women get after the 20th week of pregnancy or after giving birth. If not treated, it can cause serious problems during pregnancy, including premature birth.

Quit smoking, drinking alcohol and using harmful drugs.  

All of these can put your health and your baby’s health at risk and make you more likely to give birth early. Quitting or getting help to quit is the best thing you can do. Talk to your provider about programs that can help you quit.

To learn more about reducing your risk for premature birth, visit: marchofdimes.org

Study shows progesterone shots do not reduce preterm delivery in twin pregnancies

Friday, February 22nd, 2013

While 17P, a form of progesterone, has been shown to prevent premature delivery among about one-third of women who are pregnant with a single baby and who have experienced a prior preterm delivery, the latest research shows that 17P prescriptions can’t do the same for moms having twins.

“Twins are very high risk for preterm delivery, in fact, 60 percent of twins are born too soon. We can’t assume that what works for singleton pregnancies will work with multiples such as twins or triplets,” says Edward R. B. McCabe, MD, PhD, March of Dimes senior vice president and medical director. “This research finding is valuable because it will guide the care of women with a multi-fetal pregnancy, and highlights the need to better understand how to prevent preterm births for multiples.”

“We found that 17P was not effective in women with twin pregnancies and a short cervix (defined as less than 25 mm between 24 and 32 weeks),” says Philippe Deruelle, MD, with the Department of Obstetrics and Gynecology at Hôpital Jeanne de Flandre, Université Lille 2, France, and one of the study’s authors. “We actually seemed to have found an increase in the rate of preterm delivery before 32 weeks in the treatment group when compared to the non-treatment group.”

For the study, Dr. Deruelle and his colleagues conducted their trial on 165 women over the age of 18 at 10 university hospitals between June 2006 and January 2010. Outcome data was available for 161 of the 165 (97.6%) women. (The study’s title is Prevention of preterm delivery by 17 alpha-hydroxyprogesterone caproate in asymptomatic twin pregnancies with a short cervix: a randomized controlled trial, and was presented at the Society for Maternal-Fetal Medicine’s 33rd annual meeting last week.)

Dr. Deruelle recommends that women who know they are pregnant with twins get an ultrasound to measure their cervical length, as this factor has shown to predict which women with twins are at higher risk for premature pregnancy.

Hopefully, future research will help to shed light on ways to prevent pretem births for women who are pregnant with multiples.