Posts Tagged ‘selective serotonin reuptake inhibitors (SSRIs)’

Depression during pregnancy: What you can do

Thursday, May 24th, 2018

Depression is a serious medical condition that can affect how you feel, think and act. People with depression feel sad and lose interest in the activities they used to enjoy. Depression is far more common than many of us realize. It affects about 15 percent of women during pregnancy and the year after giving birth. Women who have depression before they conceive are at a higher risk of having depression during pregnancy than other women.

What can you do?

Learn the signs and symptoms of depression during pregnancy. Having major depression is different than feeling down for a few days. The signs or symptoms of depression last for more than two weeks. These are the signs and symptoms to look for:

Changes in the way you feel 

  • Feeling sad, hopeless or overwhelmed
  • Feeling agitated or moody
  • Crying all the time
  • Feeling worthless or guilty
  • Thinking about death or suicide

Changes in your everyday life 

  • Withdrawing from friends and family
  • Eating habits and appetite change (more or less than usual)
  • Having trouble concentrating, remembering things or making decisions
  • Sleeping too much or not being able to sleep
  • Losing interest in things you used to do

Changes in your body 

  • Feeling tired all the time or having no energy
  • Having stomach problems, headaches or other pains that don’t go away

Some of the signs and symptoms of depression may be similar to those normally found in pregnancy. For instance, changes in appetite and trouble sleeping are common when you are pregnant. Nonetheless, if you are pregnant and have any of these signs or symptoms, talk to your health care provider right away. Depression is a serious condition, and it can be dangerous for you and your baby if it’s not detected and treated on time.

Treatment

Your provider can recommend different treatments or a combination of treatments. Some of them are: counseling (therapy), support groups, or medications. It is best that you and your provider discuss all these options and decide together what treatment is best and safe for you and your baby. You can also ask your provider to talk to your mental health provider to tailor a treatment plan according to your needs.

Note about antidepressants: Some research shows that taking an antidepressant during pregnancy may increase the risk of certain birth defects in your baby. However, if you’ve been taking an antidepressant, don’t stop taking the medicine without talking to your provider first. Not taking your medicine may be harmful to your baby, and it may make your depression to come back.

More information:

Antidepressant use and the risk of ASD

Friday, December 18th, 2015

medication bottlesA new study suggests that the use of antidepressants during pregnancy, specifically in the second and third trimesters, may increase the risk of autism spectrum disorder (ASD) in children.

While these findings help to add to our understanding of autism, it is important to recognize that this study does not prove that antidepressant use causes autism. It is difficult to determine whether the increased risk of ASD is the result of antidepressants or the result of the underlying depression.

Researchers looked at data from more than 145,000 births between 1998-2009. They found that when mothers took antidepressants during the second and third trimesters, the chance that the child would develop ASD was higher when compared to children whose mothers did not take antidepressants. Keep in mind that the overall risk of having a child with autism is 1%. This study suggests that the risk increases to 1.87% if a woman is taking certain antidepressants.

The increase was seen with a specific type of antidepressants called selective serotonin reuptake inhibitors (SSRIs). SSRIs are the most commonly prescribed antidepressant medicines and include medications like citalopram (Celexa®), escitalopram (Lexapro®), fluoxetine (Prozac®), paroxetine (Paxil®) and sertraline (Zoloft®).

There are a number of causes of ASD but we don’t know all of them. More research is needed. However, there are some factors that we know increase the chance of ASD:

  • Having pregnancy complications. Some research shows that there may be a link between ASD and pregnancy complications that lead to low birthweight, premature birth or cesarean birth.
  • Taking certain prescription medicines, like valproic acid or thalidomide, during pregnancy. Taking these medicines during pregnancy has been linked with a higher risk of having a child with ASD.
  • Having an older parent. Babies born to older parents are more likely to have ASD.
  • Having genes linked to ASD. Researchers are studying a number of genes that may be linked to ASD. Children who have a brother or sister with ASD are more likely to have ASD themselves.
  • Having a genetic or chromosomal condition. ASD happens more often in children who also have certain genetic or chromosomal conditions, like fragile X syndrome or tuberous sclerosis.

Important:  If you are pregnant or thinking about getting pregnant and are taking antidepressants, you should not stop taking them until you talk to your health care provider. Together you can look at the possible risks of these drugs on your baby as well as the risk of having your depression come back if you stop taking your medicine. Learn as much as you can about the medicines so you can make the best choice for you and your baby.

Have questions? Email us at AskUs@marchofdimes.org.

New study looks at link between antidepressants and birth defects

Friday, July 10th, 2015

pregnant woman with MDThe use of certain antidepressants during pregnancy is associated with a higher risk of birth defects, according to a new study. But other antidepressants do not carry the same risk.

The study looked at a specific group of antidepressants called selective serotonin reuptake inhibitors (SSRIs). SSRIs are medications used to treat depression and other mental health conditions. Previous studies gave conflicting evidence about potential links between the use of SSRIs during pregnancy and certain birth defects.

In this study, researchers from the CDC analyzed data from 17,952 mothers of infants with birth defects and 9,857 mothers of infants without birth defects, born between 1997 and 2009.

The researchers found that some birth defects occur about two or three times more frequently among babies born to women who took certain SSRI medications, like Prozac (fluoxetine) and Paxil (paroxetine) early in pregnancy. It is important to note that the actual risk for a birth defect among babies born to women taking Prozac or Paxil is still very low. For example, the risks for a specific heart defect could increase from 10 per 10,000 births to about 24 per 10,000 births among babies of women who are treated with Paxil early in pregnancy. Since these specific types of birth defects are rare, even doubling the risk still results in a low overall chance.

Researchers did not find a link between birth defects and other SSRIs such as Zoloft (sertraline).

“A pregnant woman should be reassured that she can choose a safe drug to treat her depression and not have to go off her medication because she is afraid her baby may develop a birth defect,” Dr. Edward McCabe, Chief Medical Officer of the March of Dimes said. “Not treating depression can be unhealthy for both the mom and her baby. It can cause stress, and stress during pregnancy is associated with early births and low-birthweight babies.”

If you are currently taking an antidepressant and are concerned, do not stop taking the medication until you talk to your health care provider. And if you are planning to become pregnant and are taking an antidepressant, schedule a preconception checkup and discuss what medications may be best for you.