Posts Tagged ‘thrombophilia’

World Thrombosis Day

Tuesday, October 13th, 2015

pregnant woman blood pressureA blood clot (also called a thrombosis) is a mass or clump of blood that forms when blood changes from a liquid to a solid. The body normally makes blood clots to stop the bleeding after a scrape or cut. But sometimes blood clots can partly or completely block the flow of blood in a blood vessel, like a vein or artery. This can cause damage to body organs and even death. Blood clots affect 900,000 people each year and as many as 100,000 people die each year due to blood clots.

Risk factors for blood clots

Certain conditions make you more likely to have a blood clot. These include:

  • Being pregnant. Your blood clots more easily during pregnancy to help your body get ready to lessen blood loss during labor and birth. Also, blood flow in your legs gets slower late in pregnancy. This is because the blood vessels around your pelvis and other places are more compressed (narrow) and your growing uterus (womb) puts pressure on your pelvis.
  • Having certain health conditions, like a thrombophilia, high blood pressure, diabetes or being overweight or obese.  A family history of blood clotting problems also increases your chances of blood clots. If you have a family history or a personal history of a thrombophilia, make sure you tell your health care provider.
  • Taking certain medicines, like birth control pills or estrogen hormones. These medicines can increase the risk of clotting. If you’ve had problems with blood clots or thrombophilias or have a family history of these conditions, birth control pills may not be safe for you to use. Talk to your health care provider about other birth control options.
  • Smoking. Smoking damages the lining of blood vessels, which can cause blood clots to form.
  • Having surgery, like a cesarean section. The American College of Obstetricians and Gynecologists (ACOG) recommends that doctors help prevent blood clots in women during a c-section. This may include using devices that put pressure on your legs to help keep your blood flowing during the c-section, like compression socks.
  • Being dehydrated. This means you don’t have enough water in your body. Dehydration causes blood vessels to narrow and your blood to thicken, which makes you more likely to have blood clots.
  • Not moving around much. This may be because you’re on bed rest during pregnancy or recovering from surgery. Being still for long periods of time can lead to poor blood flow, which makes you more likely to have blood clots. Even sitting for long periods of time, like when travelling by car or plane, can increase your chances of having a blood clot.
  • Having a baby. You’re more likely to have a blood clot in the first 6 weeks after birth than women who haven’t given birth recently.

Know the signs

Make sure you recognize the symptoms of a blood clot. These include:

  • Swelling, usually in one leg (or arm)
  • Leg pain or tenderness often described as a cramp or Charley horse
  • Reddish or bluish skin discoloration
  • Leg (or arm) warm to touch

If you have any signs or symptoms, contact your health care provider right away. Blood clots can be treated with special medications.

Have questions? Text or email us at Askus@marchofdimes.org.

Thrombophilias and pregnancy

Thursday, November 29th, 2012

The thrombophilias are a group of conditions that increase a person’s chances of developing blood clots. People with a thrombophilia tend to form blood clots too easily because their bodies make either too much of certain proteins (called blood clotting factors) or too little of anti-clotting proteins that limit clot formation.

Thrombophilias may pose special risks in pregnancy. Clots are more likely to develop when a person with a thrombophilia has certain risk factors, including being pregnant or in the postpartum period (up to 6 weeks after delivery)

Most women with a tendency to develop blood clots have healthy pregnancies. However, pregnant women with a thrombophilia may be more likely than other pregnant women to develop deep vein clots and certain other pregnancy complications. Even pregnant women without a thrombophilia may be more likely than non-pregnant women to develop deep vein clots and emboli. This is due to normal pregnancy-related changes in blood clotting that limit blood loss during labor and delivery. However, studies suggest that up to 50% of pregnant women who develop a pulmonary embolus (a clot in the lung) or other venous thromboembolism (a clot that breaks off and travels to a vital organ) have an underlying thrombophilia. Pulmonary embolus is one of the leading causes of maternal death in the United States.

Factor V Leiden and prothrombin mutations are the most common inherited thrombophilias and occur in about 5% to 3% of cases, respectively. Antiphospholipid syndrome (APS) is the most common acquired thrombophilia. APS occurs in up to 5% of pregnant women. Aside from possible pulmonary embolus, APS also may contribute to repeat miscarriage, stillbirth, preeclampsia and poor fetal growth.

All pregnant women who have had a blood clot should be offered testing. Your provider also may recommend testing if you have a family history of VTE before age 50. Women who have had three or more miscarriages (before or after 10 weeks of pregnancy) or one pregnancy loss after 10 weeks of pregnancy may be offered testing for APS.

Some women may not need treatment, however women with an inherited thrombophilia who have a history of blood clots are usually treated with an anticoagulant during pregnancy and the postpartum period. It is important for any woman with a clotting disorder to discuss with her health care provider what treatment, if any, is appropriate for her specific case. A family health history of blood clots can make a significant impact on the treatment decision – another good reason to know your family health history.